EBMT NEWSLETTER | November 2017 | Volume 59 - Issue 5

Important dates

13th Edition of Lymphoma Working Party Educational Meeting
Educational Event of the Chronic Malignancies Working Party - Impact of Molecular Mutation on Transplant Descision
20th “State-of- the-Art” Educational Course of Infectious Diseases Working Party
Transplant Complications Working Party crash course on diagnosis and treatment of non infectious complications after HCT
Meeting of the Acute Leukaemia Working Party followed by the 10th Symposium « Advances in Acute Leukemia: what's new in 2017?»
Joint Educational Meeting of the Autoimmune Diseases and Inborn Errors Working Parties - Inborn Errors Working Party Annual Conference

13th Edition of Lymphoma Working Party Educational Meeting

20-22 September 2017 in Prague, Czech Republic

The city of Prague is one of the most beautiful capitals of Europe and particularly so in autumn. We were therefore very fortunate to be invited by Professor Marek Trneny from the Charles University Hospital, to attend The 13th Educational Course of the EBMT LWP in September this year.

The course attracted 48 attendees from 13 different countries to hear the very latest updates regarding lymphoma biology and treatment and the evolving role of stem cell transplantation in these diseases.

The faculty of experts covered far ranging topics including updates on the new WHO classification of lymphomas (Professor Phillipe Gaulard), the biology of mantle cell lymphoma (Professor Olivier Hermine), the role of PET scanning in malignant lymphoma (Professor Martin Hutchins) through to CAR T cells (Professor Karl Peggs) and novel therapies for T cell lymphoma (Professor Massimo Federico).

There were also presentations describing the role of transplantation in each major lymphoma subtype. There was an excellent and entertaining debate regarding the role of autologous stem cell transplantation in follicular lymphoma delivered by Dr Silvia Montoto and Dr Andrew Davies. Course attendees presented 6 challenging cases, which were discussed in depth by the faculty and attendees.

There was also a chance to relax over a glass of wine and some traditional Czech cuisine at the “meet the experts dinner” and of course to enjoy the beautiful surroundings of the city of Prague!

Save the Date! We are very pleased to invite you to the 14th Educational Course which will be held in Palma, Mallorca on 27-28 September 2018.

Educational Event of the Chronic Malignancies Working Party - "Impact of Molecular Mutation on Transplant Descision"

23 September 2017 in Ljubljana, Slovenia

After the regular business meeting of the Chronic Malignancies Working Party (CMWP) on September 23, 2017 in Ljubljana, Slovenia hosted by Matjaz Sever and his colleagues from the hematology department in Slovenia, we performed an educational event about the “Impact of molecular mutation on transplant descision in hematological malignancies”.

The educational event took place in the Grand Hotel Union in the beautiful country of Slovenia. Since the development of modern molecular techniques such as next generation sequencing also molecular mutations, especially in myeloid malignancies have been shown to have a major prognostic impact on outcome of the disease and may therefore be of interest in defining the decision for or against allogeneic stem transplantation in several hematological diseases. This very exciting development was the topic of the educational event by the Chronic Malignancies Working Party. After a historical overview about hematopoietic stem cell transplantation in the University Medical Center of Ljubljana held by Prof. Pretnar, showing the increasing activity in stem cell transplantation in the country, the educational event started with a lecture given by Benedetto Bruno from Italy about the “Molecular genetics to select patient for stem cell transplantation in Myeloma”, followed by a lecture given by Nicolaus Kröger about the “Clinical relevance of molecular genetics in Ph negative MNP”. Here, it could be shown that Calreticulin mutated patients have a significant better outcome following allogeneic stem cell transplantation even after adjustment for other prognostic factors like the dynamic IPSS. Francesca Onida presented the “Molecular genetics in CMML patients”, a disease in which more than 90% of the patients harbour at least one of the mutations. He could nicely show that even in CMML different mutations such as ASXL1 may have a significant impact on the outcome even after stem cell transplantation. Marie Robin from France summarized the increasing knowledge about molecular genetics in MDS especially impact and outcome after allogeneic stem cell transplantation.
Even, if not all the reported data are conclusive it becomes obvious that the P53-mutation had in all of the studies a prognostic impact resulting in worse outcome. The molecular mutations in CML were presented by Yves Chalandon highlighting that allogeneic stem cell transplantation has still its role in the treatment of patients with CML. Michael van Gelder presented that molecular high risk CLL patients might benefit from allogeneic stem cell transplantation despite highly active novel agents such as ibrutinib or venetoclax in this disease. At the end Matjaz Sever gave an excellent lecture about the “Experimental autologous stem cell transplantation in the heart” highlighting the enormous experience at the University Medical Center of Ljubljana in this particular research area. More than 60 participants attended the meeting which was an excellent mixture of basic research and clinical development which allows a discussion between the speaker and the audience in a friendly and inspiring atmosphere.

20th “State-of- the-Art” Educational Course of Infectious Diseases Working Party

12-14 October 2017 in Poznan, Poland

This EBMT IDWP meeting was an important and successful educational event, especially for young physicians: over 20 speakers from various countries presented their lectures, and the total number of registered attendees exceeded 100 from 16 countries, including 4 grantee-recipients, presenters of Case Reports selected and awarded by the Scientific Committee.

Apart from State-of-the-Art knowledge, the special 25th IDWP Anniversary Session and new concepts and innovative approaches in the field of infectious complications in hematopoietic cell transplantation (HSCT) setting were a crucial part of the Meeting. Previous Chairs of IDWP gave their keynote lectures: Per Ljungman “CMV”, Catherine Cordonnier “Fever investigation algorithm” and Simone Cesaro “BKV polyoma virus and hemorrhagic cystitis”.

Other lectures were presented by: Malgorzata Mikulska, Dina Averbuch, Lidia Gil, Montserrat Rovira, Martin Schmidt-Hieber, Krzysztof Kalwak, Rafael de la Camara, Olaf Penack, Dan Engelhard, Marek Ussowicz, Francis Ayuketang Ayuk, Thomas Lion, Robert Wynn, Grzegorz Basak and Jan Styczynski.
Case reports were presented by: Olga Zajac-Spychala (Poland), Sebastian Voigt (Germany), Krzysztof Czyzewski (Poland) and Igor Stoma (Belarus).  
The next 21st Educational Course of IDWP will be held in Stockholm in 2017.

Transplant Complications Working Party crash course on diagnosis and treatment of non infectious complications after HCT

19-20 October 2017 in Granada, Spain

This year’s meeting of the Transplant Complications Working Party (TCWP formerly named Complications and Quality of Life Working Party) took place in the beautiful scenery of the Royal Academia of Medicine in Granada and was kindly hosted by professor Manuel Jurado. The faculty consisting of nineteen members provided an exciting “crash course” on diagnosis and treatment of non-infectious complications after HSCT. The goal to give clear and useful clinical messages for transplant physicians was fulfilled according to more than 60 participants who attended the meeting. Scheduled lectures were short, focused and covered different areas, from pre-transplant assessment of comorbidities and early complications to long-term post-transplant management. All the lectures were followed by a brief summary based on audience interactive voting. In addition, the course was enriched with a very productive GVHD workshop - through interactive clinical cases and followed by a stimulating discussion, participants were offered an appreciated overview on the management of GVHD. The session on the endothelial damage syndromes introduced some exciting novelties in the comprehension and management of these devastating complications. We were also proud to draw attention to some of the possible interventions for the improvement of patients’ quality of life, by focusing on the most important subjects of supportive care; nutrition, physical exercise and psychological issues. Finally, in the long-term complications session, we addressed secondary cancers and metabolic syndrome as well as less familiar late complications as neurocognitive disorders. Most certainly, one of the highlights of this meeting was selected clinical cases presented by junior physicians also awarded with travel grants. These case presentations led to a stimulating atmosphere and finished with a fruitful discussion between the experts and participants.  At last, but not least, this year’s educational meeting included a special dinner in the magnificent setting overviewing the famous Alhambra. 

Meeting of the Acute Leukaemia Working Party followed by the 10th Symposium « Advances in Acute Leukemia: what's new in 2017?»

3-4 October 2017 in Paris, France

The meeting was held in the Faculté De Medicine Saint-Antoine in Paris and was hosted by Professor Mohamad Mohty. The meeting was well attended by 80 participants from around the world. On the first day, the ALWP subcommittee chairs presented the ongoing studies that were discussed and analyzed. Prof Savani discussed the emerging role of minimal residual disease for AML and the comparison of various pre transplantation conditioning that were compared head to head. Prof Giebel presented the survey of the recent trends of stem cell transplantation (SCT) for ALL in Europe and the position statement indications for SCT in ALL we put together with the European Working Group for adult Acute Lymphoblastic Leukemia (EWALL). Prof Baron focused on the recent analysis of the Seattle protocol of Flu/low dose TBI MMF/CSA for Cord Blood versus haploidentical SCT. Prof Schmid discussed the studies of prophylactic and preemptive donor lymphocyte infusions (DLIs). Prof Esteeve detailed the recent studies of SCT in various chromosomal aberrations in AML. Pr Gorin updated the group that the huge project of updating the follow up of AutoSCT was accomplished thanks to the hard work of the ALWP office and specifically Mr Mohamed Houhou. Finally Dr Ruggeri (replacing Prof Ciceri) presented the activities of the Alternative Donor Subcommittee. The second day of the meeting was divided into three sections: the morning session was devoted to pathogenesis and biology of Acute Leukemia (AML-Pr Francois Delhommeau; ALL-Prof Giovanni Martinelli); the second includes two cutting edge talks on Chimeric Antigen Receptor (CAR) T cells and the third session was clinical oriented and focused on practical questions and topics like management of fungal infections in acute leukemia; transplant algorithm in ALL and AML, the role of FLT3 inhibitors in AML and the role of Bite antibodies. The meeting was closed by the update talk of Pr Ibrahim Yakoub Agha from Lille, France on SCT in secondary AML. The lectures were well accepted and raised a lot of discussions and communications with the audience.

We would like to take this opportunity to thank both the Faculty and audients as well as our sponsors that made the meeting possible. Also we would like to thank the ALWP office statisticians Myriam Labopin and Eric Beohou and Ariane Boumendil , data managers Emmanuelle Polge , Audrey Mailhol , Mohamed Houhou, Eva Penisson and Azedine Djabali as well as the national registries and EBMT reporting centers that are making our activities possible.

Joint Educational Meeting of the Autoimmune Diseases and Inborn Errors Working Parties

3 October 2017 in Newcastle upon Tyne, UK

Inborn Errors Working Party Annual Conference

4-5 October 2017  

The first day of the conference (3rd November) was a special educational day organized in a joint effort by IEWP and ADWP entitled “Interface between Autoimmunity and Primary Immune Deficiency”.
The excellent and stimulating educational program included presentations on the activities from both WPs, PID as cause of autoimmune disease (AID), role of allo-HSCT in a AID, targeted therapies for autoimmune lymphoproliferative PID, auto-HSCT in Crohn disease, systemic sclerosis, and juvenile arthritis, and immune reconstitution after auto- and allo-HSCT. The final keynote lecture was given by Mario Abinun, a longstanding member of both IEWP and ADWP, on the role of allo-HSCT for juvenile arthritis and autoinflammatory disease.

The second day of the meeting included sessions on HSCT and gene therapy (GT) in metabolic diseases and DNA repair disorders, HSCT in emerging indications and novel primary immune disorders, and experience with SCID newborn screening in Europe and North America. The day was concluded with an outstanding keynote lecture given by Georg Holländer on the impact of PID and GvHD on thymic function.
On the final day, specific sessions focussed on HSCT and GT in beta-thalassemia, and multicenter experiences with novel strategies in haplo-identical transplantation. The meeting was concluded with a session dedicated to our current WP studies, novel study proposals including collaborative studies with our North American colleagues, and a contribution by our IEWP EBMT data officer.
The meeting was very well attended by around 130 participants mainly coming from Europe, but with a substantial number of colleagues from North America, Australia, Asia and Latin America.
We would like to thank all participants for their excellent presentations and contributions in the discussions, and Andy Gennery and Roz Scott for being perfect hosts.

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