EBMT NEWSLETTER | November 2014 | Volume 44 - Issue 2

Important dates

Chronic Malignancies Working Party preceptorship meeting

Stem Cell Transplantation in Multiple Myeloma

September 25-26 2014 in Torino, Italy

The CMWP preceptorship meeting was hosted by Benedetto Bruno. More than 60 participants attended the meeting which started with a key note lecture about the “Treatment of multiple myeloma in the past, present and future” held by Mario Boccadoro.

The meeting was structured in three intense sessions. The first covered optimal methodology, followed by a series of presentation on special issues including the roles of maintenance, consolidation, allogeneic SCT, and optimal treatment of relapse. The last session focussed on the role of stem cell transplantation in younger and older patients with multiple myeloma or rare plasmacell disorders such as POEMS syndrome or amyloidosis.  Also the exciting field of immunotherapy was targeted.
Illustrative and thought-provoking clinical cases were presented by the attendees and lively discussed.

We would like to thank everyone who contributed to the success of this encounter, especially the speakers and session chairs Holger Auner, Mario Boccadoro, Benedetto Bruno, Gösta Gahrton, Laurent Garderet, Nicolaus Kröger, Marco Ladetto, Roberto Lemoli, Massimo Massaia, Curly Morris, Antonio Palumbo and Stefan Schönland. A special thanks for the case presentations given by Yavuz Bilgin, Philip Vlummens, Isabel Cano Ferri, Maria Tenorio, Silvia Mangiacavalli and Francesca Patriarca, which contribute markedly to the success of this educational event. 

Nicolaus Kröger
CMWP Chair

EBMT Lymphoma Working Party 10th educational course

Treatment of Malignant Lymphoma: State-of-the Art and the Role of Stem Cell Transplantation

October 16-17 2014 in Nicosia, Cyprus

Chara Kyriakou, the local host, did an extremely good job in organizing this event in a beautiful historical environment (the Castelliotissa Hall, which was part of the Lusignan palace dated to the 13th-14th century). 

It has been a very well attended course with more than 60 participants coming from different places around Europe. We managed to put together highly interactive educational sessions; top level European speakers discussed the role of stem cell transplantation in lymphoproliferative disorders with special emphasis in the position of high-dose therapy and stem cell support in the era of new drugs.
These sessions were followed by very well-presented case reports from some of the participants. Very important to highlight the lively discussions that not only the key-note presentations but above all, the case reports raised. 
In summary, we have had a very fruitful meeting this year, with lots of scientific exchanges between speakers and participants in a great and friendly atmosphere. With this 10th edition, the Educational Course of the LWP has become a ‘classic’ within the EBMT educational events and we are very much looking forward to the next 2015 edition in Heidelberg.

Anna Sureda
EBMT Secretary

Peter Dreger

Inborn Errors Working Party meeting

October 17-19 2014 in Munich, Germany

This years IEWP Autumn meeting took place in Munich, over a beautiful Bavarian autumn weekend. Over 90 people attended, including participants from Australia, Brazil, and the USA.
As becomes an IEWP Autumn meeting, the presentations were fresh, with much new data being shown, and the debate was lively and intense. Sessions included metabolic disease, conditioning regimens, gene therapy, newborn screening for severe combined immunodeficiency and approach to management, outcomes of HSCT for severe combined immunodeficiency, presentations from our overseas participants, updates on current studies, and new proposals.
Alain Fischer, from Imagine, Necker Hospital, Paris, gave the keynote lecture, ‘Novel primary T cell immunodeficiencies underline multiplicity of mechanisms’ a breath-taking tour-de-force describing the genetic, molecular and functional deficiencies of 4 newly described T lymphocyte primary immunodeficiencies.

To summarise the themes of the weekend:
  • New technologies are facilitating our discovery and description of new primary immunodeficiencies at an accelerating pace, and rapidly improving our technology to manipulate the genome as we edit out faulty genes and replace them with corrected copies.
  • We continue to refine our transplantation techniques with new methods of stem cell manipulation, and use of chemotherapeutic conditioning regimens in more focused, less toxic ways.
  • Whilst survival remains an important goal, for most diseases, survival is now around 90%, and we are focusing on long-term outcomes, quality of life and metabolic or immune function.
  • The advent of newborn screening has changed our treatment approach, and will drive our quest for safer, antibody-based conditioning regimens.
Despite the growing numbers of attendees, we are still a close-knit group of friends, with common goals of developing new treatments to improve outcomes for our patients.

The beer halls of Munich and a tour of BMW World were memorable social highlights to a productive meeting.

Andrew Gennery
IEWP Chair

The EBMT Complications and Quality of Life Working Party educational course

October 23-24 2014 in Warsaw, Poland

This year’s course was held in Warsaw to celebrate the 30th anniversary of the first HSCT in Poland. It was focused on organizational perspectives of posttransplant care, GvHD and conditioning toxicity. Altogether, the course gathered a group of more than 70 participants from different countries.

First, Nina Salooja introduced the subject of late effects after HCT. The gastroenterologist (Jervoise Andreyev) and cardiologist (Stephan Zbinden) presented their stimulating thoughts about organ-specific complications. Mike Hawkins discussed the paediatric perspective on cancer survivorship. The model of nurse-led follow up of transplant recommendations was presented by Diana Greenfield, while Rafael Duarte talked over the model, how to bridge the gap between guidelines and practice. The discussion of efficacy and toxicity of non-TBI and TBI-based conditioning regimens was led by Grzegorz Basak and Sebastian Giebel, while Tapani Ruutu presented the update on the management of hepatic SOS. During the lunch session, Hildegard Greinix and Marek Ussowicz updated the audience in the subject of extracoroporeal photopheresis. Then, Hildegard Greinix presented the impact of NIH 2006 criteria on chronic GvHD, while Steven Pavletic introduced the 2014 revised NIH recommendations on diagnosis and response evaluation of cGvHD. Daniel Wolf debated on the challenges in clinical practice using the NIH criteria, and Lana Grkovic revealed details of the Croatian model of their implementation.

This year, 9 young practitioners were granted stipends which enabled them to present selected cases of posttransplant complications. Finally, during the keynote lecture, Wieslaw Wiktor-Jedrzejczak (Warsaw, Poland) introduced to the audience his perspective on transplant complications he initiated 30 years ago in Poland.
Rafael Duarte

Grzegorz W. Basak
CQLWP Secretary

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