EBMT NEWSLETTER | July 2015 | Volume 47 - Issue 2

EBMT
Important dates

JACIE 28th Inspector Training Course

July 2-3 2015 in Manchester, UK

The course was aimed at preparing new Inspectors but was open to anyone with a need to understand the accreditation process and the Standards in more detail. Thirty physicians, scientists, nurses and quality managers from the UK, Germany, The Netherlands and Slovenia attended the two-day event.

With the UK in the middle of unprecedented high temperatures, there was some significant travel disruption for participants arriving on 1 July but even that did not dampen their good humour and motivation and gave us a good excuse to enjoy the venue’s lovely terrace and lawn at the Chancellors Hotel.

The group was a good barometer of how JACIE is evolving. There was considerably more first-hand knowledge and experience of JACIE among the participants than perhaps at any time before. This collective experience offered different viewpoints than for instance from participants approaching accreditation for the first time and produced some lively and interesting discussions around standards and inspections based less on theory and more on practical experience.

The mock inspection exercise saw memorable performances by the ‘mid level physician’, ‘nurse’, ‘programme director’ and ‘quality manager’. While the scenarios are obviously designed to be over the top, some of the participants found the simulation alarmingly closer to their own experiences than one might have expected. Thank you to our 4 ‘actors’ for sharing their artistic flair.

The participation of John Snowden, Chair of the JACIE Committee, and Kim Orchard, UK National Representative – both very experienced inspectors – ensured that the requirements of the Standards were ‘translated’ into the day-to-day work of the participants. Meanwhile Robert Wynn and Wendy Ogden from the Central Manchester NHS Trust gave a great description of the centre’s point of view and needs, something that should be always kept in mind by current and future inspectors.

The participants gave very positive feedback on the course. One participant said that “the course is a great platform to communicate with JACIE and the opportunity to discuss matters with other colleagues”.  A quality manager said: “it was very valuable to see the standards from an inspector’s perspective and understand the type of evidence that is acceptable”.  A physician participant described the course “as stimulating, informative and enjoyable” while another said: “the whole course made something that could be very dry interesting”.

The course also had important new features such as approval for CME credits by the EHA and generous support from our sponsors, EUSAPharma and Therakos.

Thanks are also owed to the UK JACIE network for promoting the event. We are very hopeful to repeat the event in the UK in 2016 and will start to look at dates and venues later this year.

The next JACIE course is on 1-2 October in Barcelona, Spain. See http://www.jacie.org/news/jacie-training-course-oct2015 for more information.
 
Eoin McGrath
JACIE Operations Manager

Acute Leukaemia Working Party Workshop

Advances in alternative donor stem cell transplantation: A Euro-Mediterranean perspective

May 29-30 2015 in Marseille, France

An important mission of the ALWP is to organise educational activities on a regular basis. Each meeting is focused on a specific topic which is of major clinical importance. Through these meetings, the ALWP aims to enhance collaborations with other Working Parties of the EBMT and other academic organisations. For instance, the educational symposia organised in Milan in 2010 and in Warsaw in 2011 succeeded to get together all the European cooperative groups involved in AML and ALL.

In accordance , the ALWP recently contributed to the organisation of an extremely successful meeting that was held on May 29-30, 2015 in Marseille and focused on Haploidentical transplantation under the title "Advances in Alternative Donor Stem Cell Transplantation: A Euro-Mediterranean perspective".  158 participants attended this meeting.

Indeed, Haploidentical transplants are emerging as a very attractive form of transplant for many patients as a life saving procedure, especially those who do not have an HLA matched sibling or unrelated donor. During this event, all recent developments in the field were discussed, suggesting that Haploidentical transplantation represents a major breakthrough in the field.

Of note, two state- of- the- art lectures were delivered by Prof Leo Luznik and Ephraim Fuchs from the Baltimore group who pioneered the use of non T cell depleted Haploidentical technique administrating Cyclophosphamide post transplantation.
Prof Huang from China discussed the ATG-based Haplo approach using mobilized BM and PBSC, while Prof  Andersson from MD Anderson discussed non malignant indications.
Overall, more than twenty worldwide well-known leaders in the field of Haploidentical transplant coming from Europe, USA and Asia contributed to a very successful educative meeting. The active contribution of the experts, speakers and participants allowed to deliver a cutting edge educational event. 

Arnon Nagler
ALWP Chair

The 5th EBMT Training Course for Paediatricians and Paediatric nurses on HSCT in children and adolescents

Developing hematopoietic stem cell transplantation in Africa

May  14-17 2015 in Marrakech, Morocco

Physicians

The EBMT Paediatric Diseases Working Party held this 5th EBMT training course in order to promote this treatment modality in developing countries in Africa and the Middle East.
 
More than 40 physicians including numerous local clinicians as well as paediatricians from 8 European, 4 Mediterranean and one Asian country formed an indeed international audience and faculty.

Participants had the opportunity to meet international experts in order to discuss all aspects of Pediatric HSCT: L. Faulkner and N. Novitzky gave insight in their experiences on organizing transplant units in developing countries such as Pakistan and South Africa. A. Balduzzi gave practical hints, how to select a donor and a stem cell source. C. Peters informed about the specific characteristics of a pediatric transplant unit and P. Bader promoted haplo-transplantation as a promising treatment option particularly in developing countries, where large donor registries will not be available in the nearby future.
 
Local speakers from Morocco presented and discussed promising and difficult transplant procedures, e.g. the experience of the first allogeneic transplantation in thalassemia in Marrakech, conducted by M. Harif and his team.
 
J.H. Dalle focused on the many facets of communication in the tension field of HSCT and gave fascinating examples of successful as well as failed patient interviews.
“Be strong and brave. I did it, now it is your turn!”. M. Benihya, an adolescent former patient and receiver of a HSCT, gave this real highlight: He illuminated the patient’s side in his inimitable way.
 
The perfect local organisation of this PDWP Educational by M. Harif, J. El Houdzi and their team was crowned by an oriental evening of thousands and one night at the Horse Riding Festival in Marrakech.
 
Numerous new contacts and friendships between local physicians and the international faculty will help to further promote HSCT in developing countries, particularly in Morocco.
 
The 6th PDWP EBMT training course will be held in Copenhagen, Denmark, in 2017.
 
Peter Bader and Andre Willasch on behalf of the PDWP
 

Nurses

More than 25 nurses attended the program from 10 different countries including Morocco (from 3 different centers in Marrakesh, Rabat and Casablanca), Belgium, Switzerland, Sweden, Finland, Denmark, Italy, Saudi Arabia, Israel and Spain. Dieticians from Morocco also attended the program.

The Nurses’ program included a variety of sessions on selected topics such as the different aspects of care, safety of chemotherapy administration, isolation rules, patient and family education, GvHD, pain management, fever and neutropenia and the critically ill child. A session on vascular access included CVC care, vascular access for apheresis & ECP, nutrition aspects and cell infusion on endocrine late effects and donor issues.  Joint sessions for physicians and nurses discussed HLA typing, chronic GvHD and interestingly, there was a talk by a patient regarding his experience after undergoing an allogeneic BMT. 
 
Along the training course, we had very fruitful discussions and exchange of ideas during the experts’ breakfast meeting as there was also an open discussion on transfer of patients from the SCT unit to the ICU.  There were also informal discussions that occurred along the days of the training and in the various social events.
 
Through the meeting we also received information on the activities of the EMBMT and the outreach program of the EBMT as well as on the learning opportunities offered by EBMT such as scholarships and grants.
 
We find the training course very productive inasmuch as it was helpful, and we hope that this meeting would be the first step to increase collaboration between the EBMT and different centers in Morocco.

View the slide bank here
 
Paediatric Nurses Committee


Inborn Errors Working Party Workshop

How to transplant a patient with primary immunodeficiency

April 24 2015 in Leuven, Belgium

“The Leuven Institute for Ireland in Europe”, is one of the Irish Colleges in Europe set up to educate Roman Catholics from Ireland in their own religion after the takeover of Ireland by the Protestant English state following the Tudor conquest of Ireland. Irish colleges through Europe were important centres for the writing of Irish history and the preservation of Ireland’s rich cultural traditions.

It was in this setting in Leuven, on a beautiful, warm spring day in April, the IEWP held the first one day workshop on ‘How to transplant a patient with Primary Immunodeficiency’. The auditorium, which was the old chapel of the college, now converted, enabled a rich tradition of IEWP conversation and lively debate on the approach to HSCT in PID, to flourish. A small but select international group of trainees and more senior colleagues listened to topics on the approach to the HSCT journey for PID patients, with topics ranging from which patients to transplant, HLA typing and donor selection, pre-HSCT assessment, conditioning choices, peri-transplant care, specific complications of GvHD and infection, long-term follow up, approach to transplanting adult patients, and the role of gene therapy vs HSCT.

In the tradition of IEWP meetings, the presentations were crisp, but the debate and questions afterwards were extensive, occasionally fierce, and always instructive. We intend to weave the presentations into a manuscript, but the ideas will carry into the future, and hopefully into practice. With many thanks to Isabelle Meyts, for hosting the event so well and in such an excellent venue.

Andrew Gennery
IEWP Chair
Bookmark and Share