EBMT NEWSLETTER | January 2017 | Volume 55 - Issue 1

Important dates

3rd International Workshop on Biology, Prevention and Treatment of Relapse after Stem Cell Transplantation
Second Inborn Errors Working Party Thymic Disorders Workshop
Acute Leukemia Working Party Educational Meeting at the "Advances in Allogeneic Stem Cell Transplantation and Immunotherapy in Myeloid Malignancies" Meeting

3rd International Workshop on Biology, Prevention and Treatment of Relapse after Stem Cell Transplantation

November 4-5 2016 in Hamburg, Germany

After the successful  1st and 2nd NCI workshop held in 2009 and 2012 in Bethesda, the 3rd Workshop was organized as a joint EBMT /ASBMT  educational event to provide the latest scientific and clinical advan­ces related to relapse after HSCT and to provide a forum for the presentation of ongoing laboratory, translational, and clinical research specifically related to this field. Relapse and disease progression are the leading causes of treatment failure for most he­matologic malignancies treated with both allogeneic and autologous HSCT. This symposium continues to grow and evolve from achievements of the first two Workshops, as we have witnessed tremendous progress in our understanding and treatment of relapse in the past 10 years.

In 2 days 37 international world leading basic and translational scientists and clinical investigators from laboratory and clinic to present their exciting work in dedicated oral and poster sessions to more than 200 attendees at this workshop.

The different sessions covered topic such as epidemiology and biology of relapse, new developments in monitoring minimal residual disease (MRD), new drugs and immunotherapeutic options to prevent or treat relapse, as well as the exciting field of cellular therapy with genetically modified T-cells such as CART Cells or NK cells.
In clinical translational session the current treatment options for lymphoid and myeloid malignancies were presented by excellent speakers. In early morning “Meet the Expert” sessions , the attendees had the possibility to discuss issues in depths with the experts.

In a dedicated poster session several investigators presented their impressive results from laboaratory and clinical work. Because of the high scientific level three young investigators were awarded for a poster price:
  1.  S. Naik, Baylor College, Houston: Adoptive T-cell therapy for acute leukemia targeting multiple tumor associated antigens.
  2. C. Schmid, Augsburg: Outcome after relapse of MDS and sAML after allogeneic HSCT –  a retrospective registry analysis on 698 patients by the CMWP of EBMT
  3. F Barbor, Duesseldorf : Donors with centromeric group B and telomeric group A Killer Immunoglobulin-like Receptor haplotypes improve relapse-free survival in pediatric ALL patients after allogenic hematopoietic stem cell transplantation 
Overall, the workshop was a great success, beside its formal didactic and educational purpose, the sessions were characterized by very lively discussion and provided new ideas for attendees and faculty members for new projects in order improve the results in prevention and treatment of relapse after stem cell transplantation.

For more details, including the presentations please visit: http://e-materials.com/ebmt-relapse2016
Click HERE to view the photo gallery 

Second Inborn Errors Working Party Thymic Disorders Workshop

November 11 2016 in Leiden, The Netherlands

The second IEWP Thymic Workshop was held in Leiden on a cold late Autumn day. The first such workshop was two years ago in London, and it was timely to meet again and share new insights. The programme took us on a journey through Thymic epithelial cells lineage development, Thymic epithelial cell recovery after thymus chemoradiotherapy injury, Development of a novel strategy for thymus regeneration using 3D scaffolds and gene modification, Metabolite transporters as regulators of thymocyte differentiation, Aire expression control, Lymphotoxin in thymic regeneration and Thymic transplantation. An international faculty from The UK, US, Israel, France and Italy was joined by a small but select gathering of around 40 people, and met in the beautiful surroundings of the Stadsgehoorzaal in Leiden. The talks were excellent, and the small size and informality allowed plenty of time for questions and discussion. The day was supplemented by two presentations from junior participants – the quality of the presentations and discussion was extremely high. The importance of the thymus is frequently overlooked by transplanters, but it plays a critical role in successful transplantation. The third workshop is already being planned – watch this space.

Acute Leukemia Working Party Educational Meeting at the "Advances in Allogeneic Stem Cell Transplantation and Immunotherapy in Myeloid Malignancies" Meeting

November 25 – 27 2016 in Marseille, France

Local hosts - Prof Mohamad Mohty, EBMT President and Prof Didier Blaise, Institute Paoli Calmettes, Marseille,France.

The meeting took place at the Palais Du Pharo with the beautiful view of the old city and harbour. 240 delegates participated from all over the world including the United States, Europe, China and South America.

The 2-days meeting starts with two superb cutting edge talks: the first delivered by Prof J Dore from Paris on new insights into the microbiota, a very hot topic these days, and the second on the innate immunity delivered by Prof E Vivier from Marseille.
Welcome addresses were delivered by Professors Blaise, Mohty, Chabannon and Yakoub –Agha.

The meeting was structured in sessions. The first was entitled: "Recent updates on Haploidentical transplants for AML" and was devoted to Haploidentical transplants (HaploSCT ) and novel therapies to prevent Leukaemia relapse post transplants, as well as to new  strategies to prevent graft versus host disease (GVHD ) by combining post transplantation cyclophosphamide (PTCy)  and anti thymocyte globulin (ATG) or the suicide gene approach . Novel immunosuppressions were discussed as well. Prof Huang from China and Prof Luznik from Baltimore debates the conditioning: myeloablative vs reduced intensity for HaploSCT. Prof Vey from Marseille gave a talk  with the title "Bridging to transplant" and was devoted to novel therapies that bridge a patient with Leukaemia to allogeneic stem cell transplantation increasing his chance by reducing tumor mass, achieving a deeper and more stable response or gaining time to allocate a suitable donor or combat a serious infection.
The afternoon talks focused on "Post –transplant immune intervations" in which cutting edge technologists like engineered anti tumoral T cells manipulating the T cell receptors and chimeric antigen receptors (CARs) cells as well as  T regulatory cells and NK cells  adoptive immunotherapy were discussed by international experts from Italy and China.
The second day was devoted to new challenges in allogeneic transplantations with fascinating talks on micro transplants, bispecific antibodies (Bite Abs) and autotrasplantation  as a platform for novel immunotherapies strategies.

We would like to thank everyone who contributed to the success of this educational event, especially the speakers and session chairs, the ALWP office and mainly Ms. Emmanuelle Polge, the supporting Pharma, the local organizers and the participants.

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