Resistance Pattern of Gram-negative Bacteria Isolated from Blood from HSCT Recipients.
A non-interventional prospective multicentre study by the IDWP to determine the incidence and pattern of antimicrobials resistance among Gram-negative bacteria isolated from blood in HSCT patients during the first 6 months after the transplantation.
This study is still recruitingThere is a significant increase in resistant bacteria emerging in HSCT recipients. These resistant bacteria may be associated with increased mortality and the treatment options are limited. To provide the currently best empirical coverage and to control the growing resistance, knowledge of trends in antibiotic susceptibility as well as risk factors is essential. For this reason we would like to perform a non-interventional prospective multicentre study among EBMT centres.
Within 1 year we aim to collect 365 episodes of Gram-negative bacterial infections by following 3650 transplants recipients. The background information about the transplantations will be collected via the standard MED A form. Data on all the episodes of Gram-negative bacteria blood stream infections will be collected prospectively from the initiation of the conditioning treatment until the end of the first 6 months after the HSCT (or death or lost follow-up, if they occur earlier). Data on the patients who will develop a Gram-negative infection will be reported using a special MED C form.
Study period: February 2014 – July 2015.
Currently 94 centres are participating,
aiming to collect 6800 transplants and 600 cases of gram-negative bacteremia.
Allogeneic or autologous HSCT recipients, of all ages, for any indications.
Patients who are not willing to participate.
For participating centres:
Please note that the study period has started and that you can now report your cases of gram-negative bacteremia for patients that were transplanted after 01FEB2014.
For each separate case you should complete the MED C form. Please use the study manual while completing the form. For certain questions it might be difficult to derive the meaning from the questionnaire itself. The manual has been created to properly define those issues, in order to avoid inconsistency in the answers from the different participating centres.
It is advised to designate one person in your hospital responsible for tracking the episodes.
This study is still recruitingWhen your centre is interested in participating in this important study, or when you have any questions or concerns, please contact Jennifer Hoek of the EBMT Data Office via firstname.lastname@example.org
The Effect of 2nd generation TKI on the outcome after allogeneic SCT for Patients with CML
A Non-Interventional Prospective Study by the CMWPWe thank all participants for their ongoing cooperation in this important study!
The collection of MED B/C and follow up data is well under way. Completed forms are coming in slowly but surely. Please check whether you have completed all forms for your patients and please check especially whether the MED C form was sent to us as this form contains the questions specific for 2nd generation TKIs.
For study documents or information about the study, please contact Jennifer Hoek, study coordinator at the EBMT Data Office in Leiden, via email@example.com
MPN subcommittee of the CMWP